Impact of preimplantation genetic testing for aneuploidy on obstetrical practice
Current Opinion in Obstetrics and Gynecology
This review provides updated information on preimplantation genetic testing for aneuploidy (PGT-A), focusing on its implications on prenatal diagnostic approaches after transferal of mosaic aneuploid embryos.
A Data-Driven Evaluation of the Size and Content of Expanded Carrier Screening Panels
Obstetrics & Gynecology
The American College of Obstetricians and Gynecologists (ACOG) proposed seven criteria for expanded carrier screening (ECS) panel design. To ensure that screening for a condition is sufficiently sensitive to identify carriers and reduce residual risk of non-carriers, one criterion requires a per-condition carrier rate greater than 1-in-100.
In pregnant women with a positive BUN screen or quad screen, does secondary screening with cell-free DNA reduce the incidence of invasive testing for fetal aneuploidy?
A 2013 retrospective cohort study of 1,036 women with positive aneuploidy screening measured the use of noninvasive prenatal testing and the rate of invasive testing before and after the introduction of noninvasive prenatal testing