Over the past 5 years, the field of chronic lymphocytic leukemia (CLL) has seen the emergence of multiple new classes of therapies, including Bruton’s tyrosine kinase (BTK) inhibitors, phosphatidylinositol-3-kinase (PI3K) inhibitors, and BCL-2 inhibitors. These therapies have revolutionized treatment of the disease, but we still have much to learn about their long-term safety and efficacy, the ways they can be combined, and the ways they can be improved. In this blog post, we provide an overview of some recent research that falls into each of these three areas.
Follicular lymphoma (FL), the second most common subtype of non-Hodgkin lymphoma (NHL) and the most common indolent NHL, accounts for 35 percent of NHLs in the U.S. FL arises from germinal center B cells, which are usually CD10 positive, CD5 negative, and CD20 and CD19 positive.
Chemotherapy and more specifically chemoimmunotherapy has been standard treatment for patients with CLL. Commonly used regimens are FCR (fludarabine, cyclophosphamide, rituximab), BR (bendamustine, rituximab), and chlorambucil plus obinutuzumab.